The name luteinizing hormone derives from this effect of inducing luteinization of ovarian follicles. As its name implies, FSH stimulates the maturation of ovarian follicles.
Administration of FSH to humans and animals induces "superovulation", or development of more than the usual number of mature follicles and hence, an increased number of mature gametes. FSH is also critical for sperm production.
It supports the function of Sertoli cells, which in turn support many aspects of sperm cell maturation. GnRH is a ten amino acid peptide that is synthesized and secreted from hypothalamic neurons and binds to receptors on gonadotrophs. As depicted in the figure to the right, GnRH stimultes secretion of LH, which in turn stimulates gonadal secretion of the sex steroids testosterone, estrogen and progesterone.
In a classical negative feedback loop , sex steroids inhibit secretion of GnRH and also appear to have direct negative effects on gonadotrophs. In females, pulse frequency is clearly related to stage of the cycle. Numerous hormones influence GnRH secretion, and positive and negative control over GnRH and gonadotropin secretion is actually considerably more complex than depicted in the figure. Trends Endocrinol Metab 17 — The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
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Evidence that gonadotropin-releasing hormone stimulates gene expression and levels of active nitric oxide synthase type I in pituitary gonadotrophs, a process altered by desensitization and, indirectly, by gonadal steroids. Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src. Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor. Nuclear stabilization of beta-catenin and inactivation of glycogen synthase kinase-3beta by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope.
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Front Neuroendocrinol 31 — Your browser is not current. Microsoft Internet Explorer 6. Your browser does not support JavaScript. To use all the functions on Chemie. DE please activate JavaScript. Gonadotropin Gonadotropins are protein hormones secreted by gonadotrope cells of the pituitary gland of vertebrates.
Mechanism Gonadotropin receptors are embedded in the surface of the target cell membranes and coupled to the G-protein system. Diseases Gonadotropin deficiency due to pituitary disease results in hypogonadism , which can lead to infertility. It uses material from the Wikipedia article "Gonadotropin".
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